A pre-treatment gene expression signature of 47 SDE genes in PBMCs was associated with liver fibrosis regression (LSMred>50%) after achieving HCV clearing with HCV therapy in HIV/HCV-coinfected patients, where two SDE genes (NCAPG and NHLRC1) showed the greatest predictive capacity, which could be used as a non-invasive marker of liver fibrosis regression in patients co-infected with HIV/HCV. Here, NHLRC1 is linked to Hepatic fibrosis.