HMGB1 and acute pancreatitis: In murine models of acute pancreatitis, PFD treatment resulted in reduced serum levels of HMGB1 and C-reactive protein (Palathingal Bava et al., 2022), two inflammatory markers that have been linked to poor outcomes in clinical studies of epilepsy (Zhong et al., 2019; Chen et al., 2023a).