Furthermore, we detected 38 LCH-related genes, including KRAS, ARAF, ERBB2, MAP2K1, ERBB3, MAP2K2, and BRAF. Moreover, the patient harbored a deletion mutation in exon 12 of BRAF(c.1457_1471del), which led to an amino acid deficiency at positions 486 to 490. The gene discussed is BRAF; the disease is Langerhans cell histiocytosis.