One study found that maternal high-fructose diet-induced hypertension in multigenerational offspring is linked to an enrichment of active histone marks, such as H3Ac and H3K4me2, and a decrease in repressive histone marks, such as H3K9me3 and H3K27me3, on the pro(renin) receptor promoter (40). Here, ATP6AP2 is linked to hypertensive disorder.