Moreover, uptake of fatty acids beyond the metabolic requirements in hepatocytes results in the accumulation of triglycerides and hepatic steatosis; for example, activation of pregnane X receptor (PXR) increases hepatocyte lipid uptake and leads to steatosis by up-regulating the fatty acid transporter CD36.1, 2, 3, 4. This evidence concerns the gene NR1I2 and steatosis.