A significant number of transcription factors are involved in the modulation of the progression of hepatic steatosis and MAFL, such as SREBP1c, ChREBP, FXR, PPARα, PXR, HNF4α, liver X-activated receptor alpha (LXRα), ZBTB20, ATF3, CAR, ATF6α, CAMP responsive element binding protein 3 like 3 (CREB3L3), KLF15, p53, XBP1, YY1, C/EBPα, and THR-β (Fig. 2). The gene discussed is ATF6; the disease is fatty liver disease.