In a large cohort of 449 girls (38), 65% of girls with CPP and 26% of girls with “early normal puberty” (onset between 8 and 9 years) had a random LH > 2 SDS of a control group of girls, and a number of girls with pubertal response to GnRH had prepubertal basal LH values. This evidence concerns the gene GNRH1 and central precocious puberty.