In our opinion, defining a universally applicable GnRHa-stimulated LH cutoff value for the diagnosis of CPP is an elusive goal, given the variability and limited standardization of the different LH assays used, the variable data arising from different populations on which proposed threshold values are based, the duration of the GnRHa tests employed, and the fact that, in the continuum of pubertal progression (103), a “low” LH response at one point in time is not necessarily predictive of the speed of future progression. Here, PLOD1 is linked to central precocious puberty.