Of the girls with CPP, 7 [age 6.9 ± 0.5 years (mean ± SD), Δ(BA-CA) 1.6 years] were at Tanner stage B2, with LH < 0.25 IU/L in 5, 0.3–0.4 IU/L in 2 girls; baseline (extracted) E2 < 5 pg/ml in 5, 6–7 pg/ml in 2 girls]. This evidence concerns the gene PLOD1 and central precocious puberty.