GNRH1 and precocious puberty: Clinicians have continued to use a cutoff GnRH-stimulated LH value >5 IU/L for the diagnosis of precocious puberty (37), the same value traditionally used LH-RIA, without taking into consideration the differences between RIA and immunometric assays, between different immunometric assays, and the likely potency difference between GnRH and GnRHa (98).