Finally, 9 overlapping hub cross-talk genes between epilepsy and COVID-19 were screened out from three algorithms, including FLT3LG, PIK3R1, BCL2, ITPR3, MYD88, STAT1, TRIM21, TRIM22, and TNFSF10 (Figure 4D). The gene discussed is TNFSF10; the disease is epilepsy.