Most proteins that have been linked to familial or sporadic ALS [e.g., TAR DNA-Binding Protein 43 (TDP-43), superoxide dismutase 1 (SOD1), Fused In Sarcoma (FUS), Chromosome 9 Open Reading Frame 72 (C9orf72)] have been found to interact with mitochondria, while the presence of dysfunctional organelles and impaired mitophagy are considered as hallmarks of the disease247. Here, TARDBP is linked to amyotrophic lateral sclerosis.