C9orf72 and amyotrophic lateral sclerosis: Most proteins that have been linked to familial or sporadic ALS [e.g., TAR DNA-Binding Protein 43 (TDP-43), superoxide dismutase 1 (SOD1), Fused In Sarcoma (FUS), Chromosome 9 Open Reading Frame 72 (C9orf72)] have been found to interact with mitochondria, while the presence of dysfunctional organelles and impaired mitophagy are considered as hallmarks of the disease247.