It is known that loss of chromosome 3 and/or the presence of a BAP1 (BRCA1-associated protein 1) mutation in UM is associated with a high risk of metastasis formation, as well as with an increased density of tumor infiltrating lymphocytes and tumor associated-macrophages.49, 50, 51 The presence of tumor-infiltrating lymphocytes and macrophages may be involved in immune suppression. Here, BAP1 is linked to neoplasm.