In this decision tree, the patients are divided in T1D, T2D, or nondiabetic.The T1D cohort is divided in 2 groups: ≥18 or <18 years old. All patients receive insulin treatment. The included patients with T2D must be ≥18 years old. Therefore, in this case, the group allocation depends on the insulin requirements of the patient.Every patient treated with insulin is at risk of hypoglycemia, which can be severe or mild-moderate. A decreased frequency of hypoglycemia affects the results of the economic evaluation. The gene discussed is INS; the disease is type 1 diabetes mellitus.