IL17RA and immunodeficiency disease: While this is the first report linking a mutation in IL17RA to psoriasis in humans, a psoriasis-like skin alteration phenotype and immunodeficiency has been reported in cattle caused by recessively inherited frameshift variant in IL17RA (XP_015316220.2: p. Cys61AlafsTer62), resulting in a loss-of-function LOF effect (30).