CD8A and bladder transitional cell carcinoma: Increased numbers of CD8+ T and activated NK cells, higher scores of cytolytic activity and T cell proliferation, and fewer M2 macrophages were observed in hot tumors compared with cold tumors in BLCA (Figure 1C; Supplementary Figure 1A), CESC (Figure 1C; Supplementary Figure 1B), PAAD (Figure 1C, Supplementary Figure 1C), SARC (Figure 1C, Supplementary Figure 1D), and SKCM (Figure 1C, Supplementary Figure 1E).