At baseline, BDNF was negatively correlated with visuospatial/constructional ability score (rs=-0.437, p<0.05) and positively correlated with language score (rs=0.607, p<0.05) in MDD patients; TNF-α was positively correlated with attention score (rs=0.518, p<0.05). This evidence concerns the gene TNF and major depressive disorder.