However, when tested separately, higher levels of plasma IL-6 were significantly related only to more severe negative symptoms in those with established schizophrenia (B = 1.15; 95% CI, 0.41 to 1.89; p = .002) (Table 3), but not in those with early schizophrenia (B = 0.34; 95% CI, −0.47 to 1.14; p = .415) (Table 2). The gene discussed is IL6; the disease is schizophrenia.