Alternatively, it may be that the relationship between plasma IL-6 levels and depressive and negative symptoms may involve other or additional pathways that were not evaluated in our study, such as childhood maltreatment, which is related to low-grade inflammation (80, 81, 82), cognitive deficits (83, 84, 85), reduced structural (49,86,87) and functional (47,88) brain metrics, and poor clinical outcomes (89). Here, IL6 is linked to Cognitive impairment.