IL6 and schizophrenia: However, when tested separately, higher levels of plasma IL-6 were significantly related only to more severe depressive symptoms in those with early schizophrenia (B = 0.89; 95% CI, 0.25 to 1.52; p = .006) (Table 2), but not in established schizophrenia (B = 0.49; 95% CI, −0.22 to 1.20; p = .178) (Table 3).