After adjusting for age, sex, hypertension, hydrocephalus, the forward stepwise multivariate analysis showed that age (p < 0.001, OR = 1.07, 95%CI = 1.05–1.09), higher Graeb score (p = 0.004, OR = 2.46, 95%CI = 1.33–4.55), higher WFNS grade (p < 0.001, OR = 3.38, 95%CI = 2.06–5.52), higher H-H grade (p = 0.005, OR = 2.56, 95%CI = 1.34–4.91), surgical treatment (p < 0.001, OR = 2.77, 95%CI = 1.84–4.17), higher BNP (p = 0.047, OR = 1.49, 95%CI = 1.01–2.20) were independent risk factors of poor prognosis (Table 3). The gene discussed is NPPB; the disease is Hypertension.