Overall, curdione and borneol, the primary active ingredients of Baofukang suppositories, can effectively modulate the expression of inflammatory factors such as IL-6 and IL-1β in macrophages by inhibiting the phosphorylation of NF-κB p65 protein and nuclear translocation, thus preventing the innate immune over-activation in BV/HPV co-infection. This evidence concerns the gene NFKB1 and bacterial vaginosis.