ITGAL and neoplasm: As summarized in Table 1, we will explore LFA-1-centered interventions that may potentiate: (i) leukocyte infiltration and activation in the TME, (ii) stable LFA-1-mediated synapse formation between leukocytes and tumors to boost cytokine production and cytotoxicity, and (iii) inhibition of LFA-1-driven tumor progression and metastasis.