AQP4 and optic neuritis: A-GFAP-A can exhibit clinical features similar to MOG antibody associated disease (MOGAD) and AQP4 positive neuromyelitis spectrum disease (NMOSD); It has been reported that MOGAD (59) and NMOSD (60) may initially present with headache, fever, meningeal irritation sign, and significant white blood cell count in CSF before the characteristic symptoms of myelitis or optic neuritis.