AQP4 and demyelinating disease: Studies showed other autoimmune antibodies, including AQP4 and MOG antibodies, had been found in A-GFAP-A, indicating antibody overlapping of other demyelinating diseases with A-GFAP-A (9); One patient developing A-GFAP-A one year after being diagnosed with AQP4 antibody positive NMOSD was reported; Another patient was found to be positive for GFAP antibodies several months after being diagnosed with MOGAD (62).