Antigen-presenting cells systemically deliver tumor antigenic peptides of HSP-96, HSP-96 antigenic peptides bind to CD91 receptors on dendritic cells, the HSPPC-96 complex is internalized, and cross-delivery of cleaved tumor peptides on MHC class I and MHC class II promotes a robust CD4+ and CD8+ T-cell immune response (105–107). This evidence concerns the gene CD4 and neoplasm.