Intriguingly, these KEGG pathways and ECs we focused on, known as phenylalanine metabolism, biosynthesis of siderophore group nonribosomal peptides, and N-hydroxyarylamine O-acetyltransferase, L-rhamnose isomerase, elevated asymptotically from non-CKD status to CKD disease state, and further in CKD complicated with hypertension. Here, NAT2 is linked to hypertensive disorder.