Meanwhile, the role of TNF-α can be seen in many human malignancies, including breast (Cruceriu et al., 2020), gastric (Zhao et al., 2010), pancreatic (Egberts et al., 2008), ovaries (Gupta et al., 2016), endometrial (Morgado et al., 2016), prostate (Tse et al., 2012), bladder (Sethi et al., 2012; Ting et al., 2021), colorectal (Li et al., 2016), oral (Tang et al., 2017) and liver cancer (Roderburg et al., 2012). This evidence concerns the gene TNF and liver cancer.