Often, the NF-κB pathway, a key regulator of inflammation and immune responses, is dysregulated in BRCA, multiple myeloma, and colorectal cancer, where it facilitates cell proliferation, survival, and chronic inflammation (Karin, 2006; Annunziata et al., 2007; Greten et al., 2004). The gene discussed is NFKB1; the disease is plasma cell myeloma.