Furthermore, assessment of three independent datasets, including TCGA and two single-cell RNA sequencing datasets from Gene Expression Omnibus, in addition to immunohistochemistry data from a COAD patient cohort demonstrated that this tumor suppressor effect possibly due to its association with an increased presence of antitumor immune cells (CD8+ T cells, and CD56 NK cells), underscored CXCL11’s role in modulating the TIME (4). This evidence concerns the gene CD8A and neoplasm.