High expression of LXR genes causes upregulation of cholesterol efflux transporters such as ATP-binding cassette transporter A1 (ABCA1) and ABCG1, which facilitate cholesterol efflux and reduce lipid accumulation within macrophages, thus attenuating the inflammatory response associated with tumor progression (Joseph et al., 2003; Wang et al., 2006). Here, ABCA1 is linked to neoplasm.