MKI67 and rectum neuroendocrine neoplasm: Guidelines regarding best therapeutic approaches for high grade poorly differentiated localized rectal NETs are not well established with few similar cases reported in the literature (Table 2); however, radiation with platinum‐based chemotherapy, using a combination of etoposide and cisplatin remains the treatment of choice [9], with disparities in treatment outcomes depending on tumor proliferation marker Ki‐67 [10].