A recent clinical trial with 100 patients with CKD used EPO subcutaneous injections plus acupoint application (the medicinal ingredients: Astragalus, Eucommia, Dipsacus, raw rhubarb, Angelica, motherwort, Chuanqiong, raw oysters, Radix Aconiti) at Zusanli (ST36), Geshu (BI17), Pishu (BI20), and Shenshu (BI23) for 2 months; the patients demonstrated an increase in Hb and Hct levels in the acupoint application group, surpassing those in the control group (113). This evidence concerns the gene GSTM1 and chronic kidney disease.