Enhances androgen sensitivity and worsens the body’s inflammatory response via the TGF-β/IRF1 signaling pathway; the pathway leading to IR in PCOS may resemble that in T2DM, with regulation by the troponin I type 3(TNNI3) and Baculoviral IAP Repeat Containing 3(BIRC3) genes. The gene discussed is IRF1; the disease is polycystic ovary syndrome.