In individuals with adipose inflammation, IL-18 expression showed a negative correlation with IRS1, GLUT-4, lipocalin, and PPARγ expression (142), while demonstrating consistent changes with the severity of obesity, insulin resistance, lipid metabolism, and dyslipidemia, all indicating a significant role of IL-18 in insulin metabolism abnormalities (146–148). This evidence concerns the gene INS and obesity due to melanocortin 4 receptor deficiency.