Resveratrol mitigates proteinuria and decreases malondialdehyde concentrations in diabetic mice, while simultaneously enhancing renal cortical Mn-SOD activity, preventing apoptosis in glomerular podocytes and renal tubular epithelial cells, ameliorating histopathological alterations, and restoring the expression of Sirt1 and PGC-1α in renal tissues of DKD models. Here, SIRT1 is linked to diabetic kidney disease.