Both are present at nerve endings; V‐set and transmembrane domain‐containing two like (VSTM2L, also known as C20orf102), is a secreted protein that modulates the activity of humanin in neural cells and is involved in neurodegenerative diseases and cancer (Rossini et al. 2011; Zhang et al. 2021). The gene discussed is VSTM2L; the disease is neurodegenerative disease.