GSTP is documented to be involved in both the ovarian response to DMBA exposure (Bhattacharya and Keating 2012) and detoxification of DMBA (Henderson et al. 1998), thus an obesity-induced change in ovarian GSTP raises concern that ovotoxicity might be impacted in the obese female. The gene discussed is GSTP1; the disease is obesity due to melanocortin 4 receptor deficiency.