The proteins that were altered by obesity in both models were GC, RPLP0, EMILIN1, HSPG2, CALU, RABEP2, TSC22D1, SLMAP, FH, SERPINA6, ENSA, NAP1L1, SAE1, HPRT1, ELOB, and DENR. This evidence concerns the gene NAP1L1 and obesity due to melanocortin 4 receptor deficiency.