The proteins that were altered by obesity in both models were GC, RPLP0, EMILIN1, HSPG2, CALU, RABEP2, TSC22D1, SLMAP, FH, SERPINA6, ENSA, NAP1L1, SAE1, HPRT1, ELOB, and DENR. Here, FH is linked to obesity due to melanocortin 4 receptor deficiency.