Despite the known involvement of EPHX1 in the bioactivation of DMBA (Igawa et al. 2009), neither DMBA nor HFHS-induced obesity impacted ovarian EPHX1 protein levels in contrast to a study in which exposure to DMBA for 14 d increased ovarian EPHX1 protein in ovaries of 20-wk-old lean and hyperphagia-induced obese mice (Nteeba et al. 2014a). The gene discussed is EPHX1; the disease is obesity due to melanocortin 4 receptor deficiency.