The proteins that were altered by obesity in both models were GC, RPLP0, EMILIN1, HSPG2, CALU, RABEP2, TSC22D1, SLMAP, FH, SERPINA6, ENSA, NAP1L1, SAE1, HPRT1, ELOB, and DENR. The gene discussed is ENSA; the disease is obesity due to melanocortin 4 receptor deficiency.