GSTM1 and obesity due to melanocortin 4 receptor deficiency: Basally ovarian GSTM1 protein was higher in HFHS-induced obese compared with lean females consistent with previous observations in a different obesity model (Nteeba et al. 2014a) and is of concern because GSTM1 catalyzes the conjugation of GSH to electrophilic compounds (Nebert and Vasiliou 2004) such as DMBA metabolites.