In mdx mice (a mouse model of DMD, which carries a point mutation in the DMD gene resulting in a non‐functional dystrophin protein) administered PMO conjugated with M12, dystrophin expression was restored to approximately 25% of normal in the tibialis anterior, quadriceps, gastrocnemius, triceps and abdominal muscles, resulting in a significant improvement in grip strength. This evidence concerns the gene DMD and Duchenne muscular dystrophy.