IREB2 and metabolic dysfunction-associated steatotic liver disease: Fe2+ is a cause of steatosis liver and hepatic IR, and it is possible to slow down NAFLD and hepatic IR by inhibiting ferroptosis,23,24 and increased iron load and Fe2+ levels are usually found during NAFLD liver IR.25,26 The ferroptosis marker gene IREB2 increases its mRNA expression as ferroptosis occurs.