NFKB1 and metabolic dysfunction-associated steatotic liver disease: Factor transcription in NAFLD is typically regulated by the binding of different homologous or heterodimers, like the p65 and NF-κB consensus sequence formed by NF-κB proteins.16 Nuclear factor-κB is believed to be activated as a result of exogenous pathogen-activated TLR4 released by damaged or stressed tissues.