PPARα is considered to be a major factor regulating fatty acid β-oxidation, which can promote the intake of fat and mitochondrial fatty acid oxidation.30,31 PPARα deficiency aggravates hepatic steatosis in NAFLD by weakening fatty acid oxidation.32 FAS is responsible for regulating TG synthesis in the liver. The gene discussed is FAS; the disease is metabolic dysfunction-associated steatotic liver disease.