Furthermore, METTL3 knockdown decreased cell viability (Figure 4B), restrained cell proliferation (Figure 4C), urged cell apoptosis (Figures 4D and E), as well as repressed cell invasion (Figures 4F and G) and stemness (Figure 4H) in HCC cells, but METTL3 downregulation-mediated these effects were impaired following TRIB3 overexpression. Here, TRIB3 is linked to hepatocellular carcinoma.