Renal cortical Hpa2 expression decreased in several experimental conditions in mice: experimental glomerulonephritis induced by lipopolysaccharide; antibody treatment directed against glomerular basement membrane proteins; streptozotocin-induced diabetic nephropathy in mice; and Adriamycin (doxorubicin)-induced nephropathy [39]. Here, HPSE2 is linked to diabetic kidney disease.