Proteomic analysis of EVs secreted from colorectal cancer cells that carry mutant, kinase deficient TGF-β type II receptors, revealed an EV cargo enriched in extracellular matrix and nucleosomal proteins [47], but it is not known whether such enrichment was due to altered TGF-β signaling or whether it reflected cell adaptation to the mutation. Here, TGFB1 is linked to colorectal cancer.