ARMC5 and congenital adrenal hyperplasia: Two Armc5 deficient murine models have been generated: the complete knock-out Armc5-/- is lethal in most cases between days 6.5 and 8.5 of embryonic development [17] but the rare living pups are smaller than the wild-type ones and the aged mice develop a non-nodular adrenal hyperplasia along with high corticosterone levels [18] and have a higher risk of neural tube defects [67].