GIPR and Cushing syndrome due to macronodular adrenal hyperplasia: Indeed, in 2021, two teams have identified KDM1A germline pathogenic variants as the molecular cause of hereditary PBMAH associated with food-dependent Cushing’s syndrome [50, 51], a very rare presentation of PBMAH due to the illegitimate expression of the glucose-dependent insulinotropic polypeptide receptor (GIPR) in adrenocortical cells, reinforcing the idea that PBMAH is a genetic disease [52].