The cBioportal database analysis indicated that the majority of breast cancer patients do not harbor mutations in isocitrate dehydrogenase 1 and 2 (IDH1 and 2) and the only one case that harbors is HR + sample (Figure S1A), indicating the prevalent accumulation of D-2HG in TNBC samples was not due to IDH1/2 mutations as the common case in leukemia and glioma. Here, IDH1 is linked to glioma.