AMEND was able to recapitulate many important molecular associations with RCC, including miR-200c, miR-141, VEGFA, and HIF1A. Additionally, several enzymes involved in mitochondrial and peroxisomal lipid metabolism were captured in the module from the OGT-KO analysis, many of which corroborate previous studies of O-GlcNAc (Choline, DECR1, ACSF2). Here, ACSF2 is linked to renal cell carcinoma.