ONECUT1 and Hepatic fibrosis: One study indicated that the expression levels of transforming growth factor β1 (TGF-β1) and TGF-β receptor 2 (TGFBR2) are upregulated in the embryonic livers of HNF6-deficient mice, suggesting that HNF6 may be closely related to liver fibrosis (Tachmatzidi et al. 2021).