In this study, leveraging a combination of in vitro and in vivo experiments, RNA sequencing (RNA-seq) and methylated RNA immunoprecipitation sequencing (MeRIP-seq), we uncovered for the first time that NC may exert its anti-HCC properties by inhibiting the m6A reader protein IGF2BP3, thereby regulating the m6A modification of key genes and influencing their expression. Here, IGF2BP3 is linked to hepatocellular carcinoma.