While a critical role for platelet-derived HMGB1 has been established in coronary thrombi (Maugeri et al. 2014), experimental trauma/hemorrhagic shock (Vogel et al. 2015), and venous thrombosis (Stark et al. 2016), the present study confirms its significance in the PTS model. The gene discussed is HMGB1; the disease is Venous thrombosis.