Celastrol suppresses the release of the proinflammatory cytokines TNF-α, IL-1β, and IL-6; inhibits the PKM2-dependent Warburg effect; and binds to Cys106 in the HMGB1 protein, which helps to rebalance macrophage glycolytic metabolism, suppress M1 polarization, and alleviate lung damage caused by sepsis [209]. This evidence concerns the gene TNF and Sepsis.