When we classified human SCLC tumors by the GRN-associated genes into GRN-high (n = 45) and GRN-low (n = 90) groups (Fig. S3), GRN-low group showed better survival in both Overall Survival (OS) and progression free survival (PFS) with chemotherapy (Fig. 2A), while GRN-high group did not differ in survival with or without chemotherapy (Fig. 2B). This evidence concerns the gene GRN and small cell lung carcinoma.