Interestingly, we observed a slight, but not statistically significant increase in the number of c-Fos-positive cells in ventral CA1 cells (SPF: 35.5 ± 1.32; GF: 42 ± 2.67, Mann–Whitney test P = 0.14), consistent with the known reciprocal connection between the BLA and the ventral hippocampus (vHPC), which together form the control center for fear and anxiety-related behavior (Fig. 1H,I) (Felix-Ortiz et al, 2013). Here, FOS is linked to Anxiety.