Interestingly, although we observed a higher density of Tim3+ cells in the IT regions compared to the PT regions (Supplementary Fig 1G), majority of CD8+ infiltrates that intermingled with tumor cells were rarely positive for Tim3 in G9-highly positive tumors (Group 4 vs. Group 5 cells with Group 1 cells; Fig. 1G). This evidence concerns the gene CD8A and neoplasm.