IL6 and colorectal cancer: More recently, in >1000 patients with colorectal cancer, Kastinen and coworkers reported that tumour necrosis was significantly directly associated with the Glasgow Microenvironment score (GMS a combination tumour inflammatory cell infiltrate and tumour stroma summarised in Table 2), serum levels of interleukin-6 and CXCL8 and inversely associated with mesenteric serum levels of CXCL10 and mast cell densities in the invasive margin of the tumour [19].