Endometrial cancer cells were tested for their metastatic capacity via Transwell assays in which POLD1 was silenced, and the results demonstrated that POLD1 depletion inhibited the migratory and invasive capacities of Ishikawa, AN3CA and HEC-1A cells (Supplementary Fig. 4e, f). This evidence concerns the gene POLD1 and endometrial cancer.