Mendelian randomization analyses have been performed to assess the associations of Alzheimer’s disease, Parkinson’s disease, ALS, and neurological tumors with biological aging indicators (frailty status, telomere length, facial aging, and epigenetic aging clock acceleration)8, but no evidence of a relationship between the risk of developing ALS and biological aging8. The gene discussed is CLOCK; the disease is early-onset autosomal dominant Alzheimer disease.