TGM4 and Familial prostate cancer: Well-known markers for prostate cancer, along with proteins associated with prostate cancer and involved in EMT, including dipeptidyl peptidase 4 (DPP4), transglutaminase 4 (TGM4), keratin 7 (KRT7), acid phosphatase 3 (ACP3), kallikrein-related peptidase 3 (KLK3) and solute carrier family 45 member 3 (SLC45A3)30–35, were among the proteins driving the separation between SRCC and epithelial control in our PCA along loading component 1 (Fig. 3f)36.