TPM1 and cardiomyopathy: Most of the identified LP/P variants were located in the most well-established cardiomyopathy genes, including sarcomeric genes (n = 14, in TTN, MYBPC3, MYH7, TPM1, TNNT2, ACTC1) nuclear envelope genes (n = 3, in LMNA) and desmosomal genes (n = 2, in DSG2, PKP2) as shown in Fig. 2.