Although we identified 325 genes (Supplementary Fig. S1) to have been associated with cardiomyopathy over the three decades since the first cardiomyopathy gene (MYH7) was cloned in 199018, most identified LP/P variants in the current study—as in most studies of genetic testing in cardiomyopathies4–6,12–15—were located in a small core set of mainly sarcomeric genes. Here, MYH7 is linked to cardiomyopathy.