However, depletion of RelA significantly increased liver weight (Fig. 4B; P < 0.01), liver TG content (Fig. 4C; P < 0.01), serum ALT (Supplementary Fig. 4K; P < 0.01), and TC levels (Supplementary Fig. 4L; P < 0.05), thus exacerbating the effects of HFD-induced hepatic steatosis, and apoptosis (Fig. 4D, E; P < 0.01). The gene discussed is RELA; the disease is fatty liver disease.