Moreover, in additional primary human CRPC cells (pPC-2, pPC-3, pPC-4), the establishment of stable MTCH2 knockdown using the shMTCH2-S1-expressing lentiviral vector (as depicted in Figs. 4, 5) similarly induced Caspase-3 activation (Fig. 6G) and increased the number of TUNEL-positive nuclei (Fig. 6H), thus confirming the induction of apoptosis across multiple cancer cells. The gene discussed is CASP3; the disease is cancer.